N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396

Name	PF-431396
Synonyms	PF431396 PF-431396 PF-431396 hydrate N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396
CAS	717906-29-1

Molecular Formula	C22H21F3N6O3S
Molar Mass	506.5
Density	1.506
Solubility	Soluble in DMSO (50 mM).
Appearance	powder
Color	off-white to blue-gray
pKa	13.66±0.20(Predicted)
Storage Condition	2-8°C
Use	A dual inhibitor of FAK (focal adhesion kinase) and PYK2.
In vitro study	In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistent inhibit the increase in protein tyrosine phosphate (PY) induced by the evidence of added calcium and induced by W-7 in the presence. In A20 cells, PF-431396 blocked anti-Ig- and aggregated LFA-1-induced tyrosine phosphorylation of Pyk2 with FAK and further blocked B- cell proliferation. PF-431396 continuously inhibits protein tyrosinase phosphorylation (PY) induced by calcium deficiency and W-7 induced in the presence of calcium.

Hazard Symbols	T - Toxic
Risk Codes	R25 - Toxic if swallowed R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
WGK Germany	3

The PF-431396 is a double PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively.

Last Update：2022-10-16 17:41:48

biological activity	PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively. PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11nM and 2 nM, respectively.
In vitro study	In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phoning of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistent inhibit the increase in protein tyrosine phosphate (PY) induced by the evidence of added calcium and induced by W-7 in the presence. In A20 cells, PF-431396 blocked anti-Ig- and aggregated LFA-1 induced P yk2 phosphorylates tyrosine with FAK and further blocks B cell proliferation. PF-431396 continuously inhibits protein tyrosinase phosphorylation (PY) induced by calcium deficiency and W-7 induced in the presence of calcium.
Target	TargetValue FAK 2 nM PYK2 11 nM
Target	Value
FAK	2 nM
PYK2	11 nM

Last Update：2024-04-09 21:21:28

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CAS: 717906-29-1
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Product Name: PF-431396 Visit Supplier Webpage Request for quotation
CAS: 717906-29-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396 Request for Quotation